|
|
Colorectal cancer (CRC) is the second cause of cancer related deaths in the western world. Although improvements have been made in surgical techniques and the development of new chemotherapeutic modalities, 5-year survival rates are still around 60 %, leaving ample room for improvement.
http://dissertations.ub.rug.nl/faculties/medicine/2006/j.j.koornstra/
Experimental therapeutics induction of apoptosis in colon cancer cells by Cyclooxygenase-2 Inhibitor NS398 through a Cytochrome c-dependent pathway.
http://clincancerres.aacrjournals.org/cgi/content/abstract/7/4/1010
Apoptosis, or programmed cell death, has been a key area of focus at Genentech BioOncology™ for more than a decade.
http://www.biooncology.com/bioonc/approach/apoptosis.m?s_cid=0003&s_src=googleppc
In cancer development, the resistance of cells to apoptosis is one of the most crucial steps. Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.
http://carcin.oxfordjournals.org/cgi/content/abstract/carcin;25/5/703