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Apoptosis and Colorectal Cancer. Studies on pathogenesis and potential therapeutic targets
Colorectal cancer (CRC) is the second cause of cancer related deaths in the western world. Although improvements have been made in surgical techniques and the development of new chemotherapeutic modalities, 5-year survival rates are still around 60 %, leaving ample room for improvement.
Clinical Cancer Research
Experimental therapeutics induction of apoptosis in colon cancer cells by Cyclooxygenase-2 Inhibitor NS398 through a Cytochrome c-dependent pathway.
Apoptosis, or programmed cell death, has been a key area of focus at Genentech BioOncology™ for more than a decade.
Oxford Journals - Carcinogenesis
In cancer development, the resistance of cells to apoptosis is one of the most crucial steps. Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.;25/5/703